What is cardiac cycle and it is important
Laplace's law describes the relationship between wall thickness, wall tension and internal pressure: The wall tension necessary to maintain the pressure is proportional to the internal pressure and the internal radius, inversely proportional to the wall thickness: the larger the internal diameter, the more force the myocardium must develop less, the thicker the muscle wall (cardiomyocytes are challenged to different degrees depending on their position: subendocardials are less stressed than subepicardial ones). If the afterload increases, the wall tension in the ventricle also increases. The afterload depends not only on the pressure, but also on the geometry of the ventricle (the narrower, the lighter); as the expulsion increases, the ventricle narrows and the afterload decreases. In a healthy heart the Frank-Starling effect predominates, with ventricular dilation the Laplace effect, the ventricle becomes insufficient. Reactive hypertrophy (greater wall thickness) reduces wall tension and facilitates cardiac action
The pressure-volume diagram
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