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of the German Society for Epileptology e. V.

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1 53rd Annual Meeting of the German Society for Epileptology e. V. German Society for Epileptology e. V. Jan-Peter Kasper / FSU Jena Program March 2016 JeNa

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3 Contents Organization and Imprint ... 5 Greetings from the conference management ... 6 Greetings from the Thuringian Minister for Labor, Social Affairs, Health, Women and Family ... 7 Greetings for the 3rd Patient Day ... 8 General information ... 9 Registration ... 9 Directions City map Cloakroom Opening times Catering for breaks Poster price Types of events and contributions Publication of abstracts Lecture language Certification and advanced training points Author's information Room and exhibitor plan List of exhibitors Program overviews Scientific program Wednesday, March 2nd, Thursday, March 3rd, Friday, March 4th, Saturday, March 5th

4 Table of contents Program of the advanced training academy Wednesday, March 2, Thursday, March 3, Friday, March 4, Saturday, March 5 Poster program Patient Day, Saturday, March 5, evening and supporting program Sponsors, exhibitors and media cooperations Author index

5 Organization and imprint Location of the Friedrich Schiller University Jena campus Ernst-Abbe-Platz Jena Date March 2016 Conference homepage Organizer Deutsche Gesellschaft für Epileptologie e. V. Reinhardtstrasse 27 C Berlin Conference President Prof. Dr. Ulrich Brandl Friedrich Schiller University Jena Clinic for Pediatric and Adolescent Medicine Kochstrasse Jena Conference Secretary Dr. Gunter Skirl Friedrich Schiller University Jena Clinic for Pediatric and Adolescent Medicine Kochstrasse Jena Conference organization and organizer of industrial exhibitions, industrial symposia and supporting program Conventus Congressmanagement & Marketing GmbH Juliane Börner Carl-Pulfrich-Strasse Jena Tel Fax Program creation Design Print Edition Editorial deadline February 15, 2016 Training Academy Prof. Dr. Martin Holtkamp Charitè Universitätsmedizin Berlin Champus Charité Mitte Clinic for Neurology Clinical and Expirement Epileptology Charitéplatz Berlin 5

6 Greetings from the conference management Dear colleagues, We are particularly pleased to welcome you to the 53rd annual conference of the German Society for Epileptology e. V. in Jena. The old university town not only produced poets and philosophers, but also made significant contributions to neurology and epileptology. Not to be forgotten is the discovery of the human EEG by Hans Berger. Together with our colleagues from the program commission and the local organizing committee, we have prepared an exciting and highly topical, interdisciplinary scientific program from the submitted symposium proposals, lectures and poster presentations on all areas of epileptology. A particular focus is on improving the bridge between science and clinical practice. We want to help ensure that new findings from neuroscience, genetics or immunology find their way into clinical research and thus into the diagnosis and therapy of epilepsy. Particular attention is paid to inspiring and promoting young scientists both in the clinical field and in the basic sciences for epileptology. Numerous seminars and half-day courses are offered by the DGfE's advanced training academy for clinical training. On March 5, 2016, the congress will be enriched by the patient day, which offers many opportunities for the exchange of information between experts and those affected and their organizations. In addition to professional suggestions and personal exchange, there is an opportunity to relax in the pleasant Jena atmosphere, which is characterized by science and innovation, but also by the charm of a smaller, traditional university town. We look forward to seeing you here in Jena in March. Prof. Dr. med. Ulrich Brandl Conference President 1st Chairman of the DGfE Dr. med. Gunter Skirl Conference Secretary 6

7 Dear Sir or Madam, Greetings from the Thuringian Minister for Labor, Social Affairs, Health, Women and Family, I would like to convey the warmest greetings from the Thuringian state government to the 53rd annual meeting of the German Society for Epileptology. I am delighted that Thuringia is hosting your big annual conference this year. It illustrates once again the importance of the German Society for Epileptology. The program promises interesting presentations, lectures and discussions on all areas of epileptology. That is why I am happy to be the patron of this year's event. Epileptic seizures with their various causes can run very differently and thus also have very different effects on the everyday life of those affected. An epileptic condition is sometimes associated with a considerable reduction in the quality of life, especially with a view to the associated impairments in everyday life and all of their effects on interpersonal relationships, but also on professional life. It is therefore imperative that epilepsy be treated as early and efficiently as possible. The timely diagnosis and therapy of epilepsy continue to represent a major challenge for all departments involved in medical care, which you meet through interdisciplinary cooperation for the benefit of your patients. Particularly noteworthy is that the German Society for Epileptology unites basic researchers, clinically active doctors, psychologists and sociologists under one roof. In this way, new findings from different scientific disciplines find their way into the medical procedure more quickly. But new aids and strategies for dealing with the disease are also being developed. The 53rd annual conference impressively demonstrates this cooperation. They all make an important contribution to high-quality medical care for epilepsy patients, especially in the context of their daily work. On behalf of the state government, I thank you for this extremely competent and committed work. I wish all participants of this year's annual conference interesting, professionally enriching discussions, but also eventful hours in the university city of Jena. Warm regards from Heike Werner Thuringian Minister for Labor, Social Affairs, Health, Women and Family 7

8 Greetings for the 3rd patient day in Jena Dear Sir or Madam, More than every 20th person suffers an epileptic attack in the course of their life, almost 1% of people have epilepsy. Despite its frequency, little is said about the disease in public, politics, and the media. As a result, there is a lot of misjudgment and ignorance, which unnecessarily increases the social burden of the disease. It is therefore important for those affected to network with one another, but also with experts and politicians. On this patient day, organized by the German Society for Epilepsy (DGfE) in Jena, we want to talk about the everyday handling of the disease epilepsy in different phases of life under the motto grow and live with epilepsy. We have invited those affected and experts to report on their own experiences on the one hand and to convey the technical and scientific status of several current focus topics on the other. The patient day is aimed at epilepsy patients, families and friends of those affected and all interested citizens. Participation is free of charge. It is our goal to know you as a patient and family member are well informed, because only then is it possible to deal with the disease in the best possible way. The many voluntary members of the self-help groups, to whom we would like to pay our greatest respect at this point, also contribute. On the patient day, some self-help activists will introduce themselves and be available with advice and many valuable reports from their work. You are cordially invited to the patient day of the DGfE annual conference! We look forward to numerous visitors and a lively exchange of ideas on the many topics of our program. We look forward to your questions, suggestions and testimonials when we can welcome you to Jena on March 5, 2016 for the patient day growing and living with epilepsy. Sincerely yours, Prof. Dr. Ulrich Brandl Conference President Dr. Carsten Lekutat Patron Dr. Anika Winter Head of Patient Day Dr. Günter Krämer Co-Head of Patient Day 8

9 General information Registration Please register, preferably online, at Registration by fax or post is also possible. To do this, please download the registration form on our conference website. Fees on-site conference (every day) up to from league member Regular 210 EUR 240 EUR Reduced * 130 EUR 160 EUR Student / PJler * 50 EUR 50 EUR Non-member Regular 330 EUR 360 EUR Reduced * 130 EUR 160 EUR Student / PJler * 50 EUR 50 EUR Day tickets onsite up to from League member Regular 110 EUR 120 EUR Reduced * 70 EUR 80 EUR Student / PJler * 15 EUR 15 EUR Non-member Regular 140 EUR 150 EUR Reduced * 70 EUR 80 EUR Student / PJler * 15 EUR 15 EUR Fees evening- and supporting program Get-Together, March 2, 2016 Social evening, March 4, 2016 Regular speakers Reduced / Student / PJler * free of charge 55 EUR 30 EUR 30 EUR * Proof required: students, doctoral candidates, doctoral students, medical students in the practical year (PJler), member a self-help group (SHG), medical technical assistant (MTA), medical technical specialist (MTF), radiological-technical assistant (RTA) and nursing staff 9

10 General information Payment of fees and confirmation When registering online as well as by fax or post (registration form), you will immediately receive a written confirmation stating the account details that you can use for your transfer. This invoice is also valid for submission to the tax office. From the transfer date February 26, 2016, the transfer receipt must be presented at the check-in. Alternatively, payment by credit card (Master-Card, Visa, AmEx) is possible. Arrival by car Coming from the autobahn, take the Lobeda exit on the A4 in the direction of city center / Stadtrodaer Straße / B88 and you will get directly to the city center. Parking underground car park Krautgasse Krautgasse Jena car park Neue Mitte Jena Leutragraben 1 access via Kollegiengasse Jena Opening times entry and exit Tariffs underground car park Krautgasse car park Neue Mitte Monday Sunday, open 24 hours 1.50 EUR per 1.5 hours the Eichplatz car park and the Goethe Galerie car park can be used (price approx. EUR 0.50 / 30 min). Railway The two largest and most central railway stations in Jena are Jena West and Jena Paradies. Both are within walking distance of the city center. Airplane The closest airports are Leipzig-Halle Airport and Erfurt-Weimar Airport. Various international airlines fly to both airports regularly and they are very easy to reach by public transport. 10

11 Andrea O. Rossetti EEG pearls and pitfalls Practical Examples from the newborn to the elderly, and from the outpatients clinic to the ICU Softcover, 176 p., 235 figures, ISBN, 59.00 19.90 Special offer! World Conference Center Bonn EEG interpretation remains an art as well as a science, grounded in not just knowledge of electronics and neurophysiology, but also in the ability to recognize patterns that consist of both visual and clinical data. This collection is not intended to be encyclopedic, but rather practical, highlighting the clinical role of EEG interpretation, and the need to consider and rule out artifacts of various types EEG interpretation is best learned in the context of real cases. The atlas includes 80 case studies, illustrated as screenshots, as they may present in daily practice; they encompass a wide spectrum, ranging from common situations found on routine recordings, to under-recognized or exceptional patterns seen in ICU patients, including newborns. The form is that of a quiz: in the first part of the images are preceded by a brief clinical description to orient the interpretation. After analyzing each case, the reader may confront his / her guess with the corresponding description found in the second part. In particular, this book will help with the interpretation of uncommon normal variants, features of unknown significance, and different sorts of artifacts; some practical tips are also scattered in the text. Order via fax no / bookstore or ... Amazon 11

12 General information City map of the FSU Jena campus 12

13 General information Barcode scanners and certificates of participation For certification, the participants are asked to scan their barcodes daily at the terminals provided for this purpose. The confirmation of participation is issued automatically when scanning. Evaluation We would be delighted if you could help shape the 2017 conference today. Please use the online evaluation sheet on the conference website. Cloakroom There is the possibility to hand in cloakroom and luggage for a fee of 0.50 EUR. Hotel reservation / accommodation We have reserved room contingents for you in selected hotels under the keyword DGfE2016. You can find more information on the conference website under the heading Travel & Hotels. Please note that Conventus only acts as an intermediary and assumes no liability. Rebookings / cancellations must be made directly with the hotel. Name badge Access to the conference and the industrial exhibition is only possible with a name badge. You will receive this at the check-in or, if payment is received early enough, at the quick check-in, by scanning the QR code sent. Opening times Wednesday Thursday Friday Saturday Industrial exhibition Poster exhibition Check-in and acceptance of lectures Refreshments for breaks In the industrial exhibition area, water dispensers are available free of charge. The breaks are provided by a bistro on the ground floor of the university building, where various soft drinks, coffee and food are sold. Some companies provide catering for visitors to the industrial symposia. 13th

14 General information Poster prize Thanks to the kind support of UCB Pharma GmbH and the Epilepsy Research Association at the University of Münster e. V., the six best-placed posters will be awarded with prize money of EUR 200. The award ceremony takes place on the social evening of the DGfE e. V. on March 4, 2016, at the Volkshaus Jena. Types of events and contributions Scientific symposia In a scientific symposium, empirical work, theoretical or methodological new developments, including one's own scientific position on the topic, are presented. Poster session Abstract authors have the opportunity to present their posters in a short lecture during the poster session. These poster sessions are moderated poster tours. The guided poster sessions will take place on Thursday, March 3, 2016, in lecture hall 7 (see page 36). You can find information on the awards at the top of this page. Further training This year, too, ten half-day courses and nine seminars offer the opportunity to further and further train yourself in a wide variety of practical ways. You can find more information on the further training courses that are offered and are subject to additional fees from page 50 onwards. General Assembly The General Assembly will take place this year on Friday, March 4th, 2016 from o'clock in lecture hall 1. Epilepsy Certificate On Friday, March 4th, 2016 from Uhr, the Epilepsy Certificate can be obtained as part of an exam. The membership of the DGfE e. V. and registration are required to participate. Please contact DGfE e. Directly. V. to: 14

15 General information Publication of abstracts The abstracts for the congress will be published in the online edition of the Zeitschrift für Epileptologie from Springer Verlag. UCB Pharma GmbH supports the provision of the abstract volume on CDs. You will receive your abstract volume on CD at the company's booth (booth number 14). Video award As part of the video forum, short videos (with a lecture) with unusual paroxysmal symptoms or interesting case reports will be shown on March 2, 2016 in lecture hall 1. The audience chooses the best video that Prof. Dr. Peter and Jytte Wolf Foundation for Epilepsy is awarded EUR 500. The 2nd and 3rd place are also awarded (EUR 300 and EUR 200, respectively). Lecture language The lecture language is German, but some lectures will also be held in English. Certification and advanced training points German Society for Epileptology e. V. Whole conference 10 points 1 day 4 points Half-day course 2 points Seminar 1 point State Medical Association Thuringia Wednesday, March 2, points Thursday, March 3, points Friday, March 4, points Saturday, March 5, points 15

16 Author information Submission of your presentation / technical information Please create your presentation in the format 4: 3. A presentation device with PDF reader and MS Office PowerPoint in version 2010 or higher is provided for your presentation. The use of your own presentation device is not intended, but possible after consultation. Please bring an adapter to VGA. In the lecture hall there is a lectern with a notebook, presenter and laser pointer. A technical supervisor will assist you. Please note that different encodings for video or audio formats can lead to problems.So please visit our lecture reception in good time, at least two hours before your lecture. If you are using non-digital media, please contact us in any case. Lecture acceptance The central lecture acceptance is in room SR 120 on the upper floor. Please hand in your presentation on a storage medium with a USB connection in the lecture reception area. It is possible to test the presentation and, if necessary, edit it. Please do not protect your removable media with security software. Speaking times Please prepare your contribution in such a way that the times provided for this are adhered to. The chairpersons are requested to avoid overdrafts. Poster Please produce the posters in A0 format (84.1 cm x 118.9 cm, portrait format, unlaminated). Poster walls will be provided in lecture hall 7. Fastening material is located on the poster walls, which are provided with the corresponding numbers. Please attach your posters by Wednesday, March 2nd, 2016 at the latest, by noon. We ask the presenting authors to be present at the poster during the poster session on March 3rd in lecture hall 7. Please take your posters off again on Saturday, March 5th, 2016. No posters will be forwarded. 16

17 Room and exhibitor plan lecture hall 1 for poster exhibition and acceptance of lectures Check-in and display table Commercial exhibitors Non-commercial exhibitors Carl-Zeiss-Straße Lecture hall 3 to the cafeteria Check-In Ernst-Abbe-Platz 16 Lecture hall Lecture hall 4 Lecture hall 5 Status at the time of going to press 17

18 List of exhibitors Commercial exhibitors Actelion Pharmaceuticals Deutschland GmbH (Freiburg i. Br.) 13 AD-Tech DID medical GmbH (Simbach am Inn) 9 Aristo Pharma GmbH (Berlin) 4 Bial Portela & C a., SA (S. Mamede do Coronado / PT) 5 Brain Sentinel Inc. (San Antonio, TX / US) 22 CeGaT GmbH (Tübingen) 1 DESITIN Arzneimittel GmbH (Hamburg) 7 Dibropharm GmbH Distribution & Co. KG (Baden-Baden) 3 epitech GmbH (Hiddenhausen) 10 GVB- geliMED KG (Bad Segeberg) 18 LivaNova (Diegem / BE) 11 Medtronic GmbH (Meerbusch) 21 Micromed Neurodiagnostik UG (Halfing) 17 neuraxpharm Arzneimittel GmbH (Langenfeld) 2 Novartis Pharma GmbH (Nuremberg) 6 Nutricia GmbH (Erlangen) 20 Schwind Medical Technik (Erlangen) 8 Shire Deutschland GmbH (Berlin) 15 STRAGEN Pharma GmbH (Cologne) 12 UCB Pharma GmbH (Monheim) 14 Non-commercial exhibitors Deutsche Epilepsievereinigung e. V. (Berlin) 26 German Society for Epileptology e. V. (Berlin) 16 Dravet e. V. (Rheine) 27 e.b.e. epilepsy federal parents' association e. V. (Wuppertal) 24 State Association for Epilepsy Self-Help in North Rhine-Westphalia (Cologne) 25 State Association Epilepsy Bavaria e. V. (Nuremberg) 23 Foundation Michael a foundation for epilepsy (Bonn) As of going to press

19 Program overview Wednesday, March 2, 2016 HS 1 HS 2 HS 3 HS 4 HS 5 HS 6 14:00 16:15 14:00 16:00 14:00 16:00 14:00 15:30 14:00 15:30 Video forum p. 23 S 01 MOSES-FaMOSES- Symposium S 02 Epilepsy in Religion, Books and Film p. 24 p. 25 Seminar 1 Driving license and assessment in epilepsy Seminar 2 Epilepsy in newborns and infants p. 50 S: 30 6:00 p.m. 16 : 30 18:00 16:30 18:00 16:30 20:00 16:30 20:00 16:30 20:00 FV 1: Experimental Epileptology, Imaging p. 25 p. 26 S: 30 20:00 18: 30 20:00 18:30 20:00 S 05 Neonatal seizures S 03 Epilepsy surgery: hands off? S 06 First seizure with different causes S 04 Epilepsy and sleep a reciprocal relationship S 07 Source localization & network analysis for therapy optimization Half-day course 1 EEG in adulthood for advanced learners Half-day course 2 Presurgical epilepsy diagnosis half-day course 9 Imaging for epilepsies p. 27 p. 28 P. 28 p. 50 p. 52 p. 52 get-together from p.m. p. 74 scientific session advanced training academy * special event plenary event supporting program free lectures industrial symposium poster session internal session * can be booked separately 19

20 Program overview Thursday, March 3, 2016 HS 1 HS 2 HS 3 HS 4 HS 5 HS 6 / HS 7 08:00 09:30 08:00 09:30 08:00 09:30 08:00 10:00 08:00 09:30 08:00 10:00 FV 2: Epilepsy Surgery P. 29 S 08 Therapeutic Challenges P. 30 Seminar 3 Epilepsy, Hormones and Pregnancy P. 54 Seminar 4 Controversies in Epileptology Seminar 5 Differential Diagnosis of Paroxysmal Movement Disorders P. 55 S 09 Active Re- and dissonance while watching Dissociative seizures 10:00 12:00 p. 54 p. 32 Opening and presidential symposium S: 00 13:30 12:30 14:00 UCB Pharma GmbH 12:30 14:00 AG Genetics S 10 Modular therapy programs P. 33 S: 00 16:00 14:00 17:30 14:00 17:30 14:30 16:30 14:30 16:00 S 13 14:30 16:00 Outpatient epileptology p 11 Epilepsy in court p. 33 S 12 Status epilepticus P. 34 S: 30 17:30 Desitin GmbH Half-day course 3 Seizure semiology in children and adults Video course Half-day course 4 Drug epilepsy therapy in adults P. 36 P. 55 P. 56 S 14 Neuropsychological symposi at S: 45 6:45 p.m. Epidemiology of Epilepsy Session 6:00 p.m. 8:00 p.m. Poster inspection 20 pub crawls Young epileptologists from 8:00 p.m. p. 36 p. 74

21 Program overview Friday, March 4, 2016 HS 1 HS 2 HS 3 HS 4 HS 5 HS 6 08:00 09:30 08:00 09:30 08:00 09:30 08:00 11:30 08:00 11:30 S 15 More than anticonvulsants half-day course 6 p. 37 p. 37 p. 57 EEG for half-day course 5 advanced for sleep and epilepsy children and 10:00 11:00 10:00 11:00 10:00 11:30 adolescents 10:00 12 : 00 Novartis Pharma GmbH S 16 Update Epilepsy Genetics LivaNova Seminar 6 Non-Epileptic Seizures in Adults Seminar 7 Psychiatric Comorbidities Symposium p. 38 p. 38 Boys 11:00 12:00 p. 58 p. 57 p. 58 Epileptologists FV 4: Clinic & Genetics p. 39 S: 00 13:30 Eisai GmbH 12:30 13:30 Certificate Epilepsy p. 40 S: 00 15:30 14:00 15:30 14:00 15:30 14:00 15:30 14:00 15:30 S 20 S 17 S 18 S 19 Alternative S 21 Myths of cellular epilepsy therapy Epilepsy treatment in epileptology Long-term prognoses Pharmacotherapy Epilepsies AMNOG Pathogenesis of in times of childhood p. 40 p. 41 p. 42 p. 42 S: 00 18 : 00 16:00 18:00 16:00 17:30 16:00 17:30 16: 00 17:30 16:00 17:30 S 22 Update Epilepsy S 23 Comorbidities: Concomitant Diseases FV 3: Clinical Epileptology Seminar 8 Basics of Neuropsychology Seminar 9 Epilepsy and Employment P. 45 P. 59 P. 59 Session Individualized Therapy in Children P. 43 S: 30 7:30 p.m. General meeting p. 14 Social evening from 8:00 p.m. 21 p. 75

22 Program overview Saturday, March 5, 2016 HS 1 HS 2 HS 3 HS 4 HS 5 HS 6 SR: 00 11:30 AM 08:00 AM 11:30 AM 08:30 AM 10:30 AM 08:30 AM 10:30 AM 09:00 PM 03:30 PM S 24 Safety of people with epilepsy S 25 Immune-mediated epilepsies and encephalitides half-day course 7 Status epilepticus half-day course 8 Drug therapy of epilepsies in children / adolescents 10:00 12:30 p. 46 p. 46 Patient day 11:00 12:30 11:00 13 : 00 11:00 12:00 p. 60 p. 60 Epileptology- S 26 Quiz Epilepsy in the S 27 first year of life Update 12:00 15:30 p. 48 Classification p. 47 Film "Out of the blue: First aid easily shown" S: 30 3:30 pm 1.30 pm 3:30 pm S 28 Health Promotion in (socially) educational settings S 29 The Borderland of Epilepsy Half-day course 10 EEG in childhood and adulthood for beginners P. 72 P. 48 P. 49 S: 30 3:45 pm Farewell S

23 Scientific program Wednesday, March 2, Video forum Room HS 1 Chair Thomas Mayer (Radeberg), Thomas Bast (Kehl-Kork) Opening Thomas Mayer (Radeberg) March 2 Out of the blue Claudia Schmoldt (Eschweiler), Mireille Schauer Luisa Schauer (Dortmund ) Current language and current speaking Pitfalls in the localization of linguistic dominance Julian Lippert (Münster), Lisa Langenbruch (Osnabrück) Peter Young, Gabriel Möddel (Münster) Beautiful gifts Andreas Wagner, Anke Maren Staack, Bernhard J. Steinhoff (Kehl-Kork) Kann Do you have seizures? Gerhard Kurlemann, Erik Riesch, Oliver Schwartz, Jan Althaus Barbara Fiedler (Münster) The serious look of an infant Tatjana Kovacevic-Preradovic (Radeberg) Does smoking help with epilepsy? Steffen Syrbe (Heidelberg), Matthias K. Bernhard, Astrid Bertsche Andreas Merkenschlager (Leipzig) The smiling beauty that you should think of when you smile (for no reason) Sabrina Runge (Münster), Lisa Langenbruch (Osnabrück) Peter Young, Gabriel Möddel (Münster ) This is not my Pepe Christine Pfeiffer, Nils Holert (Radeberg) Susanne Schubert-Bast (Frankfurt a. M.), Steffi Patzer (Halle / Saale) 23

24 Scientific program Wednesday, 2nd medication on demand, useful or superfluous ?: Presentation and evaluation of the currently available emergency or on-demand medication versus the need for safety of patients and / or relatives Hartmut Baier (Ravensburg) Discussion 24

25 Scientific Program Wednesday, March 2nd S 02 Epilepsy in Religion, Books and Film Room HS 3 Chair Florian-Philip Losch, Florian Weissinger (Berlin) 2.

26 Scientific program Wednesday, March 2, March Clinical studies with new anti-epileptic drugs cover only a fraction of pharmacoresistant patients FV 03 Bernhard J. Steinhoff, Anne-Sophie Wendling Barbara Hillenbrand (Kehl-Kork) Resting state fmri assisted epilepsy syndrome classification FV 05 Helmut Laufs ( Kiel), Roman Rodionov Rachel Thornton (London / GB), Michael Siniatchkin (Kiel) John S. Duncan, Louis Lemieux (London / GB) Enzo Tagliazucchi (Kiel) Automated volumetry of the hippocampus and amygdala in FV 06 patients with temporal lobe epilepsy Carlos M. Quesada, Christian E. Elger, Bernd Weber (Bonn) S 03 Epilepsy Surgery Hands off? Room HS 2 Chair Georgia Ramantani (Zurich / CH) Thomas Bast (Kehl-Kork) Epilepsy surgery without evidence of a lesion Thomas Bast (Kehl-Kork) Epilepsy surgery for bilateral lesions Susanne Schubert-Bast (Frankfurt a. M.) Partial resections for hemispheric lesions Tom Pieper (Vogtareuth) Epilepsy Surgery for Multiple Lesions Georgia Ramantani (Zurich / CH) Discussion 26

27 Scientific program Wednesday, March 2, S 04 Epilepsy and sleep a reciprocal relationship Room HS 3 Chair Berthold R. Voges (Hamburg), Friedhelm C. Schmitt (Magdeburg) March 2, Epilepsy and somnology in children and adolescents Special syndromes with special Physiology? Michael Siniatchkin (Kiel) Differential Diagnoses of Somnological Diseases and Epilepsy an Update Björn Wito Walther (Suhl) Pathopysiological Interactions between Sleep and Epileptic Seizures Ramin Khatami (Erlinsbach / CH) Neuromodulation and Sleep The Effects of VNS and DBS Therapy on Sleep Berthold R . Voges (Hamburg) Discussion S 05 neonatal seizures Room HS 1 Chair Regina Trollmann (Erlangen), Ronit Pressler (London / GB) Diagnostic and prognostic significance of the conventional and amplitude-integrated EEG Regina Trollmann (Erlangen) Genetics and neonatal seizures Holger Lerche (Tübingen) Therapy and therapy monitoring Ronit Pressler (London / GB) Discussion 27

28 Scientific program Wednesday, March 2, March S 06 First seizure with various causes Update on diagnostics, prognosis assessment and therapy indications Room HS 2 Chair Michael Malter (Cologne), Albrecht Kunze (Jena) First acute symptomatic seizure Albrecht Kunze (Jena) First epileptic Seizure Michael Malter (Cologne) First psychogenic seizure Markus Reuber (Sheffield / GB) Status epilepticus as the first manifestation of epilepsy Martin Holtkamp (Berlin) Discussion S 07 Source localization and network analysis for therapy optimization Room HS 3 Chairman Hermann Stefan (Erlangen), Ulrich Brandl (Jena) EEG and MEG What, why? Hermann Stefan (Erlangen) Benefits for epilepsy surgery Where and how much? Stefan Rampp (Erlangen) Connectivity analysis in a multifocal epileptic network with combined EEG / MEG analysis and zoomed MRI for thermal ablation Carsten Wolters (Münster) MRI normal or unspecific Optimal diagnostic access? Friedhelm C. Schmitt (Magdeburg) Round Table Discussion 28

29 Scientific Program Thursday, March 3rd FV 2 Free Lectures 2 Epilepsy Surgery Room HS 1 Chair Ingmar Blümcke (Erlangen) Rules for Predicting Contralateral Hand Function According to FV 07 Hemispherotomy in Refractory Epilepsy Experiences from 102 pediatric cases Martin Staudt (Vogtareuth, Tübingen), Hanna Küpper (Tübingen) Tom Pieper (Vogtareuth), Samuel Gröschel (Tübingen) J.-Donald Tournier (Melbourne / AU), Hans Holthausen (Vogtareuth) Steffen Berweck (Vogtareuth, Höslwang) Manfred Kudernatsch (Vogtareuth) March 3rd Evaluation of subdural electrode displacement in invasive FV 08 monitoring by intraoperative MR imaging Björn Sommer, Stefan Rampp, Arnd Dörfler, Hermann Stefan Hajo M. Hamer, Michael Buchfelder, Karl Rössler (Erlangen) Neuropsychological result and seizure control after FV 09 anteromesial resection Thomas Sauvigny, Katja Brückner, Lasse Dührsen, Manfred Westphal Stefan RG Stodieck, Tobias Martens (Hamburg) Cognitive outcome of epilepsy surgery in children and adolescents FV 10 Hans Mayer, Karl Strobl, Adelheid Wiemer-Kruel (Kehl-Kork) Josef Zentner (Freiburg i. Br.), Thomas Bast (Kehl-Kork) Predictors of long-term freedom from seizures after FV 11 epilepsy surgery in the posterior cortex in children and adolescents Angeliki Stathi (Freiburg i. Br.), Thomas Bast (Kehl-Kork), Susanne Schubert-Bast (Frankfurt a. M.), Gert Wiegand (Kiel) Karl Strobl (Kehl-Kork), Rudolf Korinthenberg Andreas Schulze-Bonhage, Josef Zentner (Freiburg i. Br.) Georgia Ramantani (Zurich / CH) 29

30 Scientific program Thursday, March 3, March Hemiconvulsion-hemiplegia-epilepsy syndrome early FV 12 hemispherotomy with subsequent good development Tilman Polster, Thilo Kalbhenn, Kristina Lobemeier Friedrich G. Wörmann (Bielefeld), Axel Panzer (Berlin) Christian G. Bien ( Bielefeld) Mossy fiber sprouting and granule cell dispersion correlates with FV 12a the selective neuronal death in hippocampi of patients with temporal lobe epilepsy Barbara Schmeiser, Josef Zentner (Freiburg i. Br.) Thomas M. Freiman (Frankfurt a. M.) S 08 therapeutic challenges in the epilepsy treatment of adolescents, adults and the elderly Room HS 2 Chair: Susanne Schubert-Bast (Frankfurt a. M.) Adam Strzelczyk (Marburg, Frankfurt a. M.) Idiopathic generalized epilepsy Long-term outcome and therapeutic strategies Felix von Podewils (Greifswald) Women with epilepsy? Special features of contraception, pregnancy and menopause Susanne Knake (Marburg) Age-specific features and risks in the treatment of status epilepticus Adam Strzelczyk (Marburg, Frankfurt a. M.) Stimulation methods in epilepsy treatment? News on VNS, deep brain stimulation and other methods of neurostimulation Gabriel Möddel (Münster) Discussion 30

31 WORKING CONFERENCE ON NEUROINTENSIVE MEDICINE Scientific program Thursday, March 3rd, ANNUAL CONFERENCE of the German Society for NeuroIntensive Care and Emergency Medicine (DGNI) and the German Stroke Society (DSG) FEBRUARY 2017 VIENNA Conference President Prof. Dr. Jörg R. Weber Clinic Klagenfurt am Wörthersee, Austria l mrgb l fotolia.com 31

32 Scientific program Thursday, March 3, March S 09 Affective resonance and dissonance when watching dissociative seizures: seizure videos as access to the background of the illness and therapy concepts (video-based workshop, booking required) Room HS 6 Chair Martin Schöndienst (Bielefeld) Video 1 Nora Füratsch (Berlin) Video 2 Daniela Giuccioli (Bielefeld) Opening and Presidential Symposium Room HS 1 Chair Ulrich Brandl (Jena) 32 Greetings Ulrich Brandl (Jena) Greetings from the Lord Mayor of Jena Albrecht Schröter (Jena) Greetings from the Ministry of Labor, Social Affairs, Health, Women and Family Ines closing time (Erfurt) Greetings from the medical director of the Jena University Hospital Jens Maschmann (Jena) Pharmacotherapy of the future? New anti-epileptic drugs in the pipeline Heidrun Potschka (Munich) Do we really understand how anticonvulsants work? Heinz Beck (Bonn) Antiepileptogenic Therapy Wish or Reality? Christian E. Elger (Bonn) Epilepsy Genetics the Dark Side of the Genome Bernd A. Neubauer (Giessen)

33 Scientific program Thursday, March 3rd S 10 modular therapy programs as the basis of individual treatment processes in psychotherapy for epilepsy Room HS 6 Chair Gerd Heinen (Berlin), Rosa Michaelis (Herdecke) The concept of the ability to act in its meaning for psychotherapeutic processes in somatic diseases Gerd Heinen (Berlin) March 3rd, self-acting in epilepsy Conveying posture, knowledge and skills with the help of modular therapy approaches Rosa Michaelis (Herdecke) Modular therapy design in an inpatient setting Ulrike Kieliba, Kirsten Jebens (Radeberg) Discussion Industrial symposium UCB GmbH New therapy options Added value for patients? Room HS 1 Chair Soheyl Noachtar (Munich) Influence of pharmacokinetics of AEDs on tolerability Bettina Schmitz (Berlin) Brivaracetam new opportunity in epilepsy Bernhard J. Steinhoff (Kehl-Kork) New therapy options Benefit for patients Hans-Beatus Straub (Bernau) p 11 Epilepsy in court room HS 1 Chair Christian E. Elger (Bonn), Dieter Schmidt (Berlin) Epilepsy and the arbitration board of the Medical Association Dieter Schmidt (Berlin) 33

34 Scientific program Thursday, March 3rd How do insurance companies think? Randi von Wrede (Bonn) March 3rd Case studies Christian E. Elger (Bonn) Compensation for pain and suffering due to side effects of a non-indicated anti-epileptic Ulrich Brandl (Jena) Discussion S 12 Initial treatment of status epilepticus What do we know? Room HS 2 Chair: Christoph Kellinghaus (Osnabrück), Gabriel Möddel (Münster) When do I have to start the treatment? Gabriel Möddel (Münster) Benzodiazepines What do I give, when and how? Christoph Kellinghaus (Osnabrück) Anticonvulsants Alternative forms of application Jan-Christoph Schöne-Bake (Hanover) Are there non-drug forms of treatment? Adam Strzelczyk (Marburg, Frankfurt am) Discussion S 13 Outpatient Epileptology Room HS 3 Chair Thomas Mayer (Radeberg) Frank Bösebeck (Rotenburg ad Wümme) Offer of alternative treatment methods in the outpatient clinic Thomas Mayer (Radeberg) Dealing with Red Hand Letter VPA in the SPP and Epi Ambulanz Günter Krämer (Zurich / CH) 34

35 Scientific program Thursday, 3.March How do I inform my outpatients about the SUDEP risk? Bettina Schmitz (Berlin) Prescription Behavior and Adherence to Antiepileptic Drugs in Germany Hajo M. Hamer (Erlangen) MZEB Frank Bösebeck (Rotenburg ad Wümme) March 3 Diagnostic look in the epilepsy consultation hour, eye diagnoses in the physical examination Gerhard Kurlemann (Münster) p 14 Neuropsychological Symposium Cognitive Achievements in Different Epilepsy Surgical Methods Room HS 6 Chair Katja Brückner (Hamburg), Anne-Sophie Wendling (Kehl-Kork) How does age at the time of epilepsy surgery affect the cognitive processes of children? Navah Ester Kadish (Kiel) Comparison of German and French surgical strategies: selective amygdala hippocampectomy versus 2/3 resection of the temporal lobe Anne-Sophie Wendling (Kehl-Kork) What role do psychological comorbidities play in cognitive performance under deep brain stimulation in epilepsy? Katja Brückner (Hamburg) SEEG stimulation by means of deep electrodes an attempt at the presurgical clarification of special cognitive and emotional processes Michael Lanz (Hamburg) Discussion 35

36 Scientific Program Thursday, March 3rd Industrial Symposium Desitin GmbH Epilepsy Trends beyond Pharmacotherapy Room HS 3 March 3rd Current developments in therapy and diagnostics Andreas Schulze-Bonhage (Freiburg i. Br.) Genetic diagnostics and its clinical relevance Yvonne Weber (Tübingen) Poster inspection of pharmacotherapy (see p. 62) Room HS 7 Chair Heidrun Potschka (Munich) Poster inspection of epilepsy surgery (see p. 63) Room HS 7 Chair Andreas Schulze-Bonhage (Freiburg i. Br.) Poster inspection of clinical epileptology I (see p. 64) Room HS 7 Chaired by Stefan RG Stodieck (Hamburg) Poster inspection of experimental epileptology, neurophysiology, imaging (see p. 67) Room HS 7 Chair Otto W. Witte (Jena) Poster inspection of Pediatric Epileptology (see p. 68) Room HS 7 Chair Ulrich Stephani (Kiel, Schwentinental-Raisdorf) Poster inspection of clinical epileptology II and health services research (see p. 69) Room HS 7 Chair Ulrich Specht (Bielefeld) 36

37 Scientific program Friday, March 4, S 15 more than anticonvulsants Social-medical aspects in the diagnosis of epilepsy Room HS 1 Chair Tobias Knieß (Bad Neustadt / Saale), Hermann Stefan (Erlangen) The challenge of comprehensive care Hermann Stefan (Erlangen) Epilepsy and fitness to drive Günter Krämer (Zurich / CH) Epilepsy and Travel Jürgen Böhner (Bamberg) March 4th Epilepsy and Disability Law Frank Kerling (Schwarzenbruck) Epilepsy and Work Occupational Risk Assessment according to DGUV Information Tobias Knieß (Bad Neustadt / Saale) Discussion S 16 Update Epilepsy Genetics Useful information for clinical practice Room HS 2 Chair Sarah von Spiczak (Kiel, Schwentinental-Raisdorf) Yvonne Weber (Tübingen) Genetics of Epilepsies News from science and its relevance for practice Sarah von Spiczak (Kiel, Schwentinental-Raisdorf) One gene, many faces the phenotypic spectrum of SCN8A-associated epilepsies Yvonne Weber (Tübingen) Genetics of Photosensi bility Bernd A. Neubauer (Giessen) 37

38 Scientific program Friday, March 4th Genetic aspects of SUDEP the role of sodium channels in respiratory regulation Henner Koch (Tübingen) Discussion March 4th Industrial Symposium Novartis GmbH: Everolimus at TSC Update 2016 Room HS 1 Chair Hans-Beatus Straub (Bernau), Christoph Hertzberg (Berlin) Early treatment strategies in TSC Sergiusz Jozwiak (Warsaw / PL) Everolimus in everyday pediatric life Adelheid Wiemer-Kruel (Kehl-Kork) Experiences in adults Anna-Lena Friedo (Berlin) TOSCA TSC-Register Where is the journey going? Christoph Hertzberg (Berlin) Industry Symposium LivaNova: The Ictal Heart Mechanisms and Possibilities of Neuromodulation Raum HS Heart and Brain Advances Neurostimulation Closing the Cycle Markus Reuber (Sheffield / GB) Epilepsy Therapy with Heart Berthold R. Voges (Hamburg) Symposium Young Epileptologists Raum HS 6 Chair Felix von Podewils (Greifswald), Adam Strzelczyk (Marburg, Frankfurt a. M.) The symposium of young epileptologists has been an established part of the annual conference of the DGfE since 2015 and presents lectures by renowned speakers alternating with young scientists. The symposium is dedicated to current issues in epileptology and is intended to promote interdisciplinary and cross-generational exchange. 38

39 Scientific program Friday, March 4th One year of young epileptologists Jan-Christoph Schöne-Bake (Hanover) Prize winner presentation of the Dieter Janz Prize Epilepsy Surgery in Children through the Ages Hans Holthausen (Vogtareuth) New neuropathological classification easy to understand for clinician Roland Coras (Erlangen ) Semiology and prevalence of dissociative seizures and psychological abnormalities in epilepsy Christoph Baumgartner (Vienna / AT) March 4th Psychological interventions and dealing with the unforeseeable in epilepsy Rosa Michaelis (Herdecke) Psychotherapeutic care of dissociative seizures Christoph Winkler (Kehl-Kork) Outlook and goals of the boys Epileptologist Eva-Lotta von Rüden (Munich) FV 4 Free Lectures 4 Clinic and Genetics Room HS 2 Chair Soheyl Noachtar (Munich), Christian G. Bien (Bielefeld) Family nocturnal frontal lobe epilepsy due to an FV 18 NPRL3 mutation G. Christoph Korenke (Oldenburg ), Marlene Eggert (Munich) Holger Thiele, Peter Nürnber g, Thomas Sander (Cologne) Ortrud K. Steinlein (Munich) Cbl D1 defect A rare but treatable cause of FV 19 early childhood epilepsy Natalia Lüsebrink, Martin Lindner, Matthias Kieslich (Frankfurt a. M.) 39

40 Scientific program Friday, March 4, Treatment results from a specialized epileptological FV 20 care after a first unsuccessful attempt at therapy in people with epilepsy Theresa Prasse, Johannes Rösche (Rostock) March 4, Postoperative antiepileptic drug treatment and its effect on FV 21 seizure outcome following mesiotemporal praise epilepsy surgery Barbara Schmeiser, Josef Zentner Andreas Schulze-Bonhage (Freiburg i. Br.) Industry Symposium Eisai GmbH the latest from diagnostics and therapy Room HS 1 Chair Hajo M. Hamer (Erlangen), Martin Holtkamp (Berlin) Neurocognition in epilepsy When to test what , and with what? Christian Hoppe (Bonn) Eslicarbazepine Acetate Update clinical data Martin Holtkamp (Berlin) Epilepsy therapy in Germany Influences beyond the guideline Hajo M. Hamer (Erlangen) S 17 myths of pharmacotherapy Room HS 1 Chair Andreas Schulze-Bonhage (Freiburg i. Br.) Thomas Mayer (Radeberg) Pro: individual therapy resistance of an anti-epileptic means dosing up to the tolerance limit without reaching freedom from seizures Hartmut Baier (Ravensburg) Cons: individual therapy resistance of an anti-epileptic means dosing up to the tolerance limit without reaching freedom from seizures Stefan RG Stodieck (Hamburg) 40

41 Scientific program Friday, March 4th Pro: there is no longer any indication for long-term therapy for old AEDs with strong enzyme induction (CBZ, PB, PRM, DPH) Christian E. Elger (Bonn) Cons: there is no longer any indication for long-term therapy of old AEDs with strong enzyme induction (CBZ, PB, PRM, DPH) Bernhard J. Steinhoff (Kehl-Kork) Pro: sodium substitution in drug-induced hyponatremia Felix Rosenow (Marburg, Frankfurt a. M.) Cons: sodium substitution in drug-induced hyponatremia Andreas Schulze-Bonhage (Freiburg i. Br.) March 4th Sufficient: Alternatives to valproate in young women with generalized epilepsy Günter Krämer (Zurich / CH) Poor: Alternatives to valproate in young women with generalized epilepsy Markus Leitinger (Salzburg / AT) Discussion S 18 Cellular Pathogenesis of Epilepsies: Glia, Autoimmunity and Dendrites an Update Room HS 2 Chair Christian Geis (Jena), Heinz Beck (Bonn) Glia Is the uncoupling of Astroz yten the cause of a TLE? Christian Steinhäuser (Bonn) Synaptic Transmission GABA as an excitatory transmitter in epilepsy? Knut Kirmse (Jena) 41

42 Scientific Program Friday, March 4th Dendrites, tiny appendages of nerve cells Does the seizure begin here? Heinz Beck (Bonn) Autoantibodies against neuronal proteins What happens to the nerve cells? Christian Geis (Jena) March 4th Discussion S 19 Epilepsy Therapy in Times of AMNOG Room HS 3 Chair Hajo M. Hamer (Erlangen), Ulrich Brandl (Jena) AMNOG and anticonvulsants Hajo M. Hamer (Erlangen) AMNOG in the (Neuro-) Pediatric Ulrich Brandl (Jena) AMNOG from the point of view of those affected Susanne Fey (Wuppertal) Additional benefit in epilepsy therapy from the point of view of the G-BA Wiebke Löbker (Berlin) Discussion S 20 alternative epilepsy treatment in childhood beyond surgery and VNS Room HS 4 Chair Gerhard Kurlemann ( Münster), Astrid Bertsche (Leipzig) On witches and herbs in epilepsy treatment Also in children? Gerhard Kurlemann (Münster) 42

43 Scientific Program Friday, March 4th How do parents feel about alternative therapies in the treatment of their children's epilepsy? Astrid Bertsche (Leipzig) What else is possible? Gerhard Kurlemann (Münster) Discussion S 21 long-term prognoses in epileptology Room HS 5 Chair Martin Holtkamp (Berlin), Friedhelm C. Schmitt (Magdeburg) March 4th in idiopathic generalized epilepsies Felix von Podewils (Greifswald) under therapy with individual anti-epileptics Martin Holtkamp (Berlin) after resective epilepsy surgery in children and adolescents Tilman Polster (Bielefeld) after partial temporal lobe resection in adults, vagus nerve and deep brain stimulation Friedhelm C. Schmitt (Magdeburg) Discussion S 22 Update Epilepsy The most important scientific papers of the last 12 months Room HS 1 Chairman Bernhard J. Steinhoff (Kehl-Kork), Holger Lerche (Tübingen) Basics Heidrun Potschka (Munich) Genetics Holger Lerche (Tübingen) 43

44 Scientific program Friday, March 4th Imaging Jörg Wellmer (Bochum) Preoperative diagnostics and epilepsy surgery Anke Maren Staack (Kehl-Kork) Non-operative therapy Bernhard J. Steinhoff (Kehl-Kork) March 4th Discussion S 23 comorbidities in persons with epilepsy and intellectual disability: accompanying illnesses in people with epilepsy and intellectual disabilities Room HS 2 Chair Christian Brandt, Bernd Huber (Bielefeld) Behavioral comorbidities in persons with epilepsy and intellectual disability (ID) Mike Kerr (Cardiff / GB) Influence of comorbidities on burden of disease in persons with epilepsy and ID Christine Linehan (Dublin / IE) Concomitant physical illnesses and general health issues Christian Brandt (Bielefeld) New version of PEPE, the epilepsy training program for people with learning or intellectual disabilities Bernd Huber (Bielefeld) Discussion 44

45 Scientific program Friday, March 4th FV 3 Free lectures 3 Clinical Epileptology Room HS 3 Chair Bernd A. Neubauer (Gießen), Tilman Polster (Bielefeld) Martian moments Data for an application trial of an FV 13 epilepsy course for adolescents with epilepsy Gerd Heinen (Berlin) Evaluation of the anticonvulsive treatment in children with FV 14 therapy-difficult epilepsy a retrospective study of an epilepsy outpatient clinic Silvia Vieker, Jörg Schmitt (Herdecke) March 4th Epilepsy-related concerns of relatives and carers of FV 15 epilepsy patients with additional intellectual disabilities: factor structure, scales and predictors of the German version the Glasgow Epilepsy Outcome Scale (GEOS) Theodor W. May, Rupprecht Thorbecke, Birgit Müffelmann Christian Brandt, Michael Endermann, J. Lena Hopf Helga Ottenottebrock, Claudia Wolfertz Christian G. Bien (Bielefeld) Does epilepsy therapy make long-term sickness? FV 16 Maxi Burkhardt, Christoph Kurth, Matthias Bacher Iancu Bucurenciu, Barbara Hillenbrand, Reinhold Kornmeier Anke Maren Staack, Bernhard J. Steinhoff (Kehl-Kork) Nodding Syndrome in Mahenge, Tanzania session on ictual EEG FV 17 patterns Thomas Wagner (Heidelberg), Josua Kegele (Tübingen) Thomas Bast (Kehl-Kork), Erich Schmutzhard (Innsbruck / AT) Andrea-Sylvia Winkler (Munich) 45

46 Scientific Program Saturday, March 5th S 24 Update on new aspects of the safety of people with epilepsy Room HS 2 Chair Bernhard J. Steinhoff (Kehl-Kork), Rainer Surges (Bonn) Genetic and imaging biomarkers of an increased risk of SUDEP Rainer Surges (Bonn) March 5, Evidence-based effective control of generalized tonic-clonic seizures an update Bernhard J. Steinhoff (Kehl-Kork) Status quo and development opportunities for the safety of inpatient epilepsy patients in German-speaking countries Andreas Schulze-Bonhage (Freiburg i. Br. ) SUDEP education from the doctors' and patient's point of view Still a taboo? Adam Strzelczyk (Marburg, Frankfurt a. M.) Moderation Round Table Discussion Bernhard J. Steinhoff (Kehl-Kork) S 25 Immune-mediated epilepsies and encephalitis: Different antibodies Different clinical characteristics? Room HS 3 Chair Michael Malter (Cologne), Albrecht Kunze (Jena) GAD Michael Malter (Cologne) NMDA-R Harald Prüß (Berlin) LGI1 Albrecht Kunze (Jena) 46

47 Scientific program Saturday, March 5th H Gaba receptors and rare neurogenic antigens Christian G. Bien (Bielefeld) GENERATE a network for research into autoimmune encephalitides Nico Melzer (Münster) Discussion S 26 Epilepsy in the first year of life Challenge in a vulnerable phase of the CNS Development Room HS 2 Chair Gerhard Kurlemann (Münster), Astrid Bertsche (Leipzig) Clinic for Epilepsies in the First Year of Life Barbara Fiedler (Münster) March 5th Differential Diagnosis of Epilepsies in the First Year of Life Gerhard Kurlemann (Munster) Diagnosis of Epilepsies in the First Year of Life (Genetics Imaging ) Steffen Syrbe (Heidelberg) Treatment of (therapy-difficult) epilepsies in the first year of life Susanne Schubert-Bast (Frankfurt a. M.) Discussion S 27 Update classification room HS 3 Chair Christian E. Elger (Bonn), Markus Leitinger (Salzburg / AT) Classification of seizures Thomas Mayer (Radeberg) 47

48 Scientific program Saturday, March 5th Classification of the status epilepticus according to the proposal of the ILAE task force 2015 Markus Leitinger (Salzburg / AT) Classification of epileptic syndromes What has changed due to the new classification proposals? Tilman Polster (Bielefeld) Classification of Epileptic Syndromes Suggestions for Current Practical Handling Ulrich Brandl (Jena) March 5th Round Table Discussion Thomas Mayer (Radeberg), Tilman Polster (Bielefeld) Ulrich Brandl (Jena), Martin Holtkamp (Berlin) Bernhard J. Steinhoff (Kehl-Kork), Christian E. Elger (Bonn) Markus Leitinger (Salzburg / AT) Epileptology Quiz Room HS 6 Chair Günter Krämer (Zurich / CH) S 28 Health promotion in (social) educational settings Room HS 2 Chair Ingrid Coban ( Bielefeld), Peter Brodisch (Munich) Case Management in Social Work and Interdisciplinary Interfaces Ingrid Coban (Bielefeld), Frank Kerling (Schwarzenbruck) Nobody is sick alone Systemic family counseling for epilepsy Karin Kimmerle-Retzer (Munich) Disability Severe disability Compensation for disadvantages ?: When is a handicapped ID is useful? Maria Lippold (Radeberg), Michaela Pauline Lux (Kehl-Kork) Discussion 48

49 Scientific program Saturday, March 5, S 29 the Borderland of Epilepsy Interfaces in the diagnosis and therapy of seizure disorders Room HS 3 Chair Frank Bösebeck (Rotenburg ad Wümme) Adam Strzelczyk (Marburg, Frankfurt a. M.) Overview of episodic disorders and phenomena Frank Bösebeck (Rotenburg ad Wümme) Myoclonus Hans-Michael Meinck (Heidelberg) Seizure-like symptoms in vascular insults and migraines Adam Strzelczyk (Marburg, Frankfurt a. M.) Episodic disorders in sleep Gabriel Möddel (Münster) March 5 Dissociative seizures Hypotheses on pathogenesis based on patient descriptions Joachim Opp (Oberhausen) Farewell room HS 3 Chair Ulrich Brandl (Jena) 49

50 Program of the advanced training academy Wednesday, March 2nd Seminar 1 Driving license and assessment for epilepsy Room HS 4 Chair Günter Krämer (Zurich / CH), Ulrich Specht (Bielefeld) On the way to an individualized assessment ?: new data and trends on fitness to drive Ulrich Specht (Bielefeld) Liability issues in neurology / epileptology Peter Wolfgang Gaidzik (Hamm) Current aspects in the assessment of epilepsy Günter Krämer (Zurich / CH) March 2nd Seminar 2 Epilepsy in newborns and infants Room HS 5 Chair Gabriele Wohlrab (Zurich / CH) , Peter Borusiak (Wuppertal) Seizure semiology of neonatal seizures Indication of the etiology? Gabriele Wohlrab (Zurich / CH) Etiology, therapy and outcome in neonatal seizures Peter Borusiak (Wuppertal) Therapy-difficult epilepsies in young babies Edda Haberlandt (Innsbruck / AT) HTK 1 EEG in adulthood for advanced students Room HS 4 Chair Frithjof Tergau (Hildesheim), Hajo M. Hamer (Erlangen) Peak potential in the EEG Frithjof Tergau (Hildesheim) Seizure pattern in the EEG (with video EEG examples) Hajo M. Hamer (Erlangen) 50

51 60th Annual Scientific Conference Program of the Advanced Training Academy Wednesday, March 2, 2016 German Society for Clinical Neurophysiology and Functional Imaging davis / instantly - fotolia.com March 2, 2016 Düsseldorf with Richard-Jung-Kolleg Advanced Training Academy and II. International Conference on Deep Brain Stimulation Main Topics Neuromodulation Central Neurophysiology Functional and Structural Neuroimaging Neuroplasticity Peripheral Neurophysiology Central Movement Disorders Dementia Pain Multiple Sclerosis Stroke Epilepsies Neuromuscular Disorders Sleep Disorders Neurorehabilitation History of the DGKN Free Topics 51

52 Program of the advanced training academy Wednesday, March 2nd Drug effects in the EEG Christoph Kurth (Kehl-Kork) What an adult neurologist needs to know about the children's EEG Tom Pieper (Vogtareuth) HTK 2 Presurgical Epilepsy Diagnostics Room HS 5 Chair Soheyl Noachtar (Munich) Andreas Schulze-Bonhage (Freiburg i. Br.) Who is eligible for presurgical epilepsy diagnostics? Andreas Schulze-Bonhage (Freiburg i. Br.) 2.March Imaging methods in presurgical epilepsy diagnostics Christian Vollmar (Munich) Non-invasive epilepsy surgery diagnostics Matthias Hoppe (Bielefeld) Invasive epilepsy surgery diagnostics Soheyl Noachtar (Munich) HTK 9 imaging in epilepsy room HS 6 Chair Hans-Jürgen Huppertz (Zurich / CH) Friedrich G . Wörmann (Bielefeld) Introduction to MRI technology including suitable sequences and protocols for epilepsy as well as presentation of the anatomy and most common epileptogenic lesions Friedrich G. Wörmann (Bielefeld) Epileptogenic lesions in MRI and preoperative planning Irina Mader (Freiburg i. Br.) 52

53 Program of the advanced training academy Wednesday, March 2nd Spectrum of epileptogenic lesions at a tertiary epilepsy center and possibilities of MRI postprocessing Hans-Jürgen Huppertz (Zurich / CH) Our most unusual cases Friedrich G. Wörmann (Bielefeld) Irina Mader (Freiburg i. Br. ) Hans-Jürgen Huppertz (Zurich / CH) paulrommer - fotolia.com ESC th EUROPEAN STROKE CONFERENCE l APRIL 2016 l VENICE (ITALY) 53

54 Program of the advanced training academy Thursday, March 3rd Seminar 3 Epilepsy, Hormones and Pregnancy Room HS 3 Chair Susanne Fauser (Ulm), Stefan R.G. Stodieck (Hamburg) Influence of anti-epileptic drugs on hormones and hormonal contraception Prevention in epilepsy Stefan R.G. Stodieck (Hamburg) Antiepileptic Drugs in Pregnancy Teratogenic and Cognitive Effects Susanne Fauser (Ulm) Case Discussions Stefan RG Stodieck (Hamburg), Susanne Fauser (Ulm) Seminar 4 Controversies in Epileptology Room HS 4 Chaired by Gerhard Kurlemann (Münster), Thomas Mayer (Radeberg ) March 3rd New Definitions of Epilepsy What are the consequences? Gerhard Kurlemann (Münster), Thomas Mayer (Radeberg) No more valproate in women of childbearing potential How do we deal with it? Gerhard Kurlemann (Münster), Thomas Mayer (Radeberg) Early use of new anti-epileptic drugs Pros and Cons Thomas Mayer (Radeberg) Stopping anti-epileptic drugs When, how quickly, with whom? Gerhard Kurlemann (Münster) 54

55 Program of the advanced training academy Thursday, March 3rd Seminar 5 Differential diagnosis of paroxysmal movement disorders Room HS 5 Chair Yvonne Weber (Tübingen), Bernd A. Neubauer (Gießen) Proxysmal dyskinesias with transition to epilepsy Yvonne Weber (Tübingen) Differential diagnosis of paroxysmal movement disorders in children Bernd A. Neubauer (Gießen) Episodic Ataxias Carolin Muth (Munich) HTK 3 Seizure Semiology in Children and Adults Video Course Room HS 4 Chaired by Dirk-Matthias Altenmüller (Freiburg i. Br.) Matthias Hoppe (Bielefeld) Seizure signs in focal epilepsies from symptom to localization Dirk- Matthias Altenmüller (Freiburg i. Br.) March 3rd Dissociative seizures Spectrum and differential diagnosis of epileptic seizures Nora Füratsch (Berlin) Focal vs. generalized seizures Diagnostic assignment based on semiology (video EEG) always possible? Matthias Hoppe (Bielefeld) From emotions to cyanosis typical semiology in childhood Kerstin Alexandra Klotz (Freiburg i. Br.) 55

56 Program of the advanced training academy Thursday, March 3rd HTK 4 Drug Epilepsy Therapy in Adults Room HS 5 Chair Heidrun Potschka (Munich), Christian G. Bien (Bielefeld) Mechanisms of action of anticonvulsants and their importance for effectiveness Heidrun Potschka (Munich) Current study results How can I transfer it to my own medical practice? Christian G. Bien (Bielefeld) Pharmacotherapy for patients with contraceptives, the desire to have children and during pregnancy Birgit Müffelmann (Bielefeld) Side effects of anticonvulsants and their recording in everyday clinical practice Berthold R. Voges (Hamburg) March 3rd

57 Program of the advanced training academy Friday, March 4th Seminar 6 non-epileptic seizures in adults Room HS 3 Chair Markus Reuber (Sheffield / GB), Martin Finzel (Radeberg) Diagnosis of non-epileptic seizures Markus Reuber (Sheffield / GB) No explanation of the diagnosis -epileptic seizures Markus Reuber (Sheffield / GB) Further therapy of non-epileptic seizures: multimodal therapy program Martin Finzel (Radeberg) Psycho- / trauma therapy for non-epileptic seizures Kirsten Jebens (Radeberg) HTK 5 Sleep and Epilepsy Room HS 4 Chair Rainer Surges ( Bonn), Pascal Grosse (Berlin) Fundamentals of sleep and its disorders Pascal Grosse (Berlin) Sleep-related breathing disorders and epilepsy Ramin Khatami (Erlinsbach / CH) March 4th Interactions between sleep and epilepsy Rainer Surges (Bonn) Practical exercise for the differential diagnosis of nocturnal episodes Stefan RG Stodieck (Hamburg) 57

58 Program of the advanced training academy Friday, March 4th HTK 6 EEG for advanced users in children and adolescents Room HS 5 Chair Christine Charlotte Makowski (Munich) Tilman Polster (Bielefeld) Video EEG in the diagnosis of premature and newborn babies Ronit Pressler (London / GB ) EEG in pediatric emergency and intensive care medicine Christine Charlotte Makowski (Munich) Video EEG in the diagnosis of childhood epilepsy syndromes Judith Kröll (Zurich / CH) Video EEG in pre-surgical epilepsy diagnosis Tilman Polster (Bielefeld) Seminar 7 Psychiatric comorbidities in adults and children / Adolescents with epilepsies Room HS 3 Chair Regina Trollmann (Erlangen), Tim Joachim von Oertzen (Linz / AT) March 4th Psychiatric comorbidities in adults with epilepsies with case studies Tim Joachim von Oertzen (Linz / AT) Disorders of behavior and cognition in children and adolescents with epilepsy with case studies Regina Trollmann (Erlangen) 58

59 Program of the advanced training academy Friday, March 4th Seminar 8 Basics of neuropsychology in epileptology What is important for practice? Room HS 4 Chair Juri-Alexander Witt (Bonn), Dörthe Heinemann (Bern / CH) The Role of Neuropsychology in Epileptology Juri-Alexander Witt (Bonn) Neuropsychology in Presurgical Epilepsy Diagnostics Dörthe Heinemann (Bern / CH) Seminar 9 Epilepsy and Employment Room HS 5 Chair Ingrid Coban (Bielefeld), Peter Brodisch (Munich) Training planning and career entry in the case of existing epilepsy Ingrid Coban (Bielefeld) Basics of an occupational health risk assessment for occupational profiles and occupational activities Peter Brodisch (Munich), Ingrid Coban (Bielefeld) Professional participation and Reorientation in the case of new epilepsy Peter Brodisch (Munich) March 4th

60 Program of the advanced training academy Saturday, March 5th HTK 7 Status epilepticus room HS 4 Chair Stephan Rüegg (Basel / CH), Christoph Kellinghaus (Osnabrück) Clinical phenomenology Symptoms, problems with classification, differential diagnosis Susanne Knake (Marburg) EEG for status epilepticus Markus Leitinger (Salzburg / AT) Discussion of pre-hospital therapy for status epilepticus Christoph Kellinghaus (Osnabrück) Status epilepticus and the immune system What role do infections and autoimmune phenomena play? Stephan Rüegg (Basel / CH) Discussion HTK 8 Drug Therapy of Epilepsies in Children / Adolescents Room HS 5 Chair Ingo Borggräfe (Munich), Peter Borusiak (Wuppertal) March 5th Therapy guidelines for frequent pediatric epilepsy syndromes Ingo Borggräfe (Munich) Use of new anti-epileptic drugs for epilepsy in childhood Bernd A. Neubauer (Gießen) treatment of status epilepticus Peter Borusiak (Wuppertal) procedure for therapy-difficult epilepsy in childhood Thomas Bast (Kehl-Kork) 60

61 Program of the advanced training academy Saturday, March 5th HTK 10 EEG for children and adults for beginners Room HS 5 Chair Jan Rémi (Munich), Helmut Laufs (Kiel) Technical basics (differential derivation, system, electrodes, amplifier, Nyquist, sampling rate, etc. .), Localization rules, choice of montage, advantages of different montages Soheyl Noachtar (Munich) slowdowns and their differential diagnoses, encephalopathies Helmut Laufs (Kiel) typical epilepsy potentials and their differential diagnoses Jan Rémi (Munich) activation procedure Rainer Surges (Bonn) March 5th

62 Poster Pharmacotherapy P 01 Classical neurotransmitters and neuropeptides involved in generalized epilepsy How can the antiepileptic effect be improved? Felix-Martin Werner (Pößneck), Rafael Coveñas (Salamanca / ES) P 02 P 03 P 04 P 05 P 06 The clinical effect of perampanel does not correlate with the serum concentrations Elisabeth Hübers, Uta Jürges, Barbara Hillenbrand Bernhard J. Steinhoff (Kehl- Kork) First study patient, now under perampanel 5 years seizure-free case report Bernhard J. Steinhoff, Anke Maren Staack (Kehl-Kork) Christina Kirchhoff (Kehl-Kork, Lahr) Barbara Hillenbrand (Kehl-Kork) Comparison of lacosamide concentrations in saliva and in the serum of epilepsy patients Christian Brandt, Renate Helmer, Christian G. Bien Theodor W. May (Bielefeld) Change in the blood-liquor barrier according to status epilepticus Tessa Huchtemann, Helmut Feistner, Hans-Jochen Heinze Peter Körtvélyessy (Magdeburg) Severe lupoid course of a rheumatoid arthritis under Zebinix a case presentation Lena Habermehl, Ilka Immisch, Leona Möller Anna Maria Sikeler (Marburg), Uwe Lange (Bad Nauheim) Adam Strzelczyk, Felix Rosenow (Marburg, Frankfurt a. M.) Katja Menzler, Susanne Knake (Marburg) POSTER P 07 Stiripentol as a healing attempt for the treatment of refractory, focal epilepsy in adult patients: 2 testimonials Ilka Immisch, Katja Menzler, Anna Maria Sikeler Lena Habermehl (Marburg), Adam Strzelczyk Felix Rosenow (Marburg , Frankfurt a. M.) Susanne Knake (Marburg) 62

63 Poster P 08 P 09 P 09 a P 09 b Personalized treatment for severe epileptic encephalopathy due to KCNA2 mutation Freedom from seizures and positive effects on accompanying symptoms due to 4-aminopyridine Thomas Bast (Kehl-Kork), Ulrike Hedrich, Matthis Synofzik Niels Focke, Saskia Biskup, Holger Lerche (Tübingen) Lacosamide in people with intellectual disabilities: a long-term study on 136 patients Stefan Böttcher, Thomas Mayer, Martin Lutz (Radeberg) Serine biosynthesis defect with mutation in the PSAT1 gene as a very rare cause of epilepsy, as well as a developmental, behavioral and movement disorder a case report Andrea Dieckmann, A. Fuchs, Ralf A. Husain, Ulrich Brandl (Jena) Investigation of lipid mediators as potential antiepileptic drugs and drug targets in epileptic seizure models Julia Post, Raissa Lerner, Sebastian Loch, Beat Lutz Laura Bindila (Mainz) Epilepsy surgery P 10 Conduction aphasia as a diagnostic guide in a patient with a left temporal lobe pilepsie Lara Kay, Sebastian Bauer (Marburg, Frankfurt a. M.) Anja Haag (Marburg), Anke Hermsen (Marburg, Frankfurt a. M.) Katja Menzler (Marburg), Philipp S. Reif (Marburg, Frankfurt a. M.) Karina Wulf (Marburg), Ulrich Sure (Essen) Susanne Knake (Marburg), Felix Rosenow Adam Strzelczyk (Marburg, Frankfurt a. M.) P 11 P 12 Deficits in the processing of response conflicts in epilepsy patients with hippocampal sclerosis Markus Ramm, Gabriel Möddel, Peter Young Lisa Langenbruch (Münster), Conrad Baumann (Aachen) Carina R. Oehrn (Bonn), Nikolai Axmacher (Bochum) Ability to learn and remember with structural hippocampal integrity Juri-Alexander Witt, Christian E. Elger, Albert J. Becker (Bonn) Ingmar Blümcke (Erlangen), Christoph Helmstädter (Bonn) POSTER 63

64 Poster P 13 P 14 P 15 P 16 P 17 Change in seizure frequency in a patient with cortical dysplasia on the left fronto-operculo-island after invasive monitoring and stereotactic thermal ablation Leona Möller, Anna Maria Sikeler, Kristina Krause, Barbara Carl Katja Menzler, Susanne Knake (Marburg) Long-term courses in patients after epilepsy surgery over 5 years Henning Schmitz-Peiffer, Heinz Reichmann, Gabriele Schackert Matthias Kirsch, Susanne Hallmeyer-Elgner (Dresden) Treatment of Epileptogenic Hypothalamic Hamartomas by Stereotactic Radiofrequency Thermocoagulation Christine Steiert, Kathrin Wagner, Andreas Schulze- Bonhage Volker A. Coenen, Peter C. Reinacher (Freiburg i. Br.) Seizure reduction only in the late long-term course with ANT stimulation A case report Dominik Thuberg, Lars Büntjen, Jürgen Voges, Uta Beyer Klaus Kopitzki (Magdeburg), Tilman Polster (Bielefeld) Martin Holtkamp (Berlin), Hans-Jochen Heinze Friedhelm C. Schmitt (Magdeburg) Deep brain stimulation n in patients with temporal lobe attacks: stronger influence on sleep in responders Arne Ilse, Friedhelm C. Schmitt (Magdeburg), Wolfgang Hamel Patrick M. House, Christian K. E. Moll (Hamburg) Harim Lee (Magdeburg), Stefan R.G. Stodieck Berthold R. Voges (Hamburg) POSTER Clinical Epileptology I P 18 Body position in generalized tonic-clonic seizures: Is the prone position a risk factor for SUDEP? Rainer Surges (Bonn), Sharon Shmuely (Heemstede / NL) Josemir Sander (Heemstede / NL; London / GB) Christian E. Elger (Bonn), Roland Thijs (Heemstede / NL) 64

65 Poster P 19 P 20 P 21 Temporal lobe seizures and Undine syndrome Anti-Hu and Zic4 associated paraneoplastic limbic and brain stem cephalitis Franziska Trienekens (Marburg) Sebastian Bauer (Marburg, Frankfurt a. M.), Andreas R. Koczulla Damiano Librizzi, David Vadasz , Susanne Knake (Marburg) Felix Rosenow, Adam Strzelczyk (Marburg, Frankfurt a. M.) Gains through cardiological diagnostics of patients with unclear seizures in an epilepsy center Damiano Librizzi, David Vadasz, Susanne Knake (Marburg) Christoph Dietze, Lucy Ekosso -Ejangue, Carsten W. Israel Christian G. Bien (Bielefeld) TOSCA TuberOus SClerosis registry to increase disease awareness baseline data with a focus on TSC-associated epilepsy Christoph Hertzberg, Klemens Budde Susanne Brakemeier (Berlin) Matthias Sauter (Kempten, Munich) Michael Fischereder (Munich), Andreas Hahn Paula Kreuzaler (Gießen), Adelheid Wiemer-Kruel (Kehl-Kork) Gerhard Kurlemann (Münster), Hans Hartmann (Hanover) Klaus Marquard (Stu ttgart), Regina Trollmann, Imke Lorenz Stephanie Nögel (Erlangen), Bernd Wilken Ann-Katrin Kolb (Kassel), Andreas Merkenschlager (Leipzig) Steffen Syrbe (Heidelberg), Markus Knuf (Wiesbaden) Ramon Castellana (Barcelona / ES), Stefania Crippa Gabriella Gislimberti (Origgio / IT), Bulent Ulker (Basel / CH) Anna Jansen (Brussels / BE), John C. Kingswood (Brighton / GB) POSTER 65

66 Poster P 22 P 23 P 24 P 25 Estimation of the general cognitive performance level in epilepsy patients Can a social estimation formula as a bedside test replace a short form of the Wechsler intelligence test for adults? Lara Kay, Sebastian Bauer (Marburg, Frankfurt a. M.) Anja Haag (Marburg), Anke Hermsen (Marburg, Frankfurt a. M.) Katja Menzler (Marburg) Philipp S. Reif (Marburg, Frankfurt a. M.), Karina Wulf (Marburg) Ulrich Sure (Essen), Susanne Knake (Marburg) Felix Rosenow, Adam Strzelczyk (Marburg, Frankfurt a. M.) How paraneoplastic are limbic encephalitis ?: a full-body PET-CT study Svenja Stuff, Hojjat Ahmadzadehfar , Christian E. Elger Guido Widman (Bonn) Anti-neuronal antibodies in late-onset partial epilepsies: a population-based study Felix von Podewils, Marie Suesse, Julia Lange, Alexander Dressel Christof Kessler, Uwe Runge (Greifswald) Christian G. Bien (Bielefeld) Paraneoplastic LGI1 antibody-associated limbic encephalitis in a patient with rectal cancer Fatme Seval Ismail, Jörg Wellmer (Bochum), Ralf Schmidt (Herne) Uwe Schlegel (Bochum), Christian G. Bien (Bielefeld) Wenke Grönheit (Bochum) POSTER P 26 Epilepsy and its treatment in Nicolaides-Baraitser Syndrome Benedikt Hofmeister (Höslwang, Vogtareuth) Steffen Berweck (Vogtareuth, Höslwang) Celina von Stülpnagel-Steinbeis (Vogtareuth; Salzburg / CH) Cornelia Betzler (Vogtareuth), Peter Weber (Basel / CH) Jansen Katrien (Leuven / BE), Edda Haberlandt (Innsbruck / AT) Stefan Schilling (Regensburg), Birgit Häckl Gerhard Kluger (Vogtareuth; Salzburg / AT) 66

67Ludolph Susanne Fauser (Ulm) Tractography of the medial limbic circuit in mesial temporal lobe epilepsy due to hippocampal sclerosis Karl Egger, Julia M. Nakagawa, Marco Reisert, Kilian Rutkowski Armin Brandt, Andreas Schulze-Bonhage Horst Urbach (Freiburg i. Br.) P 32 Feasibility study on the use of 9.4 Tesla MR imaging in patients with cryptogenic focal epilepsy Pascal Martin, Joana Loureiro, Gisela Hagberg, Jonas Bause Ravitejah Kotikalapudi, Michael Erb, Holger Lerche, Klaus Scheffler Niels Focke (Tübingen) POSTER P 33 Individualized MEG residual state examinations in patients with focal epilepsy Justus Marquetand, Yiwen Li Hegner, Adham Elshahabi Niels Focke, Holger Lerche, Silke Klamer-Ethofer (Tübingen) 67

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